What is tPBM?
Transcranial photobiomodulation (tPBM) is a form of light therapy that uses low level or near infrared light (NIR) placed on the scalp. Targeting delivery of light energy to the brain, tPBM is associated with increased cerebral blood flow, oxygen availability and consumption, promote cellular energy by increasing adenoside triphophosphate (ATP) production, and modulating neuronal activity. Transcranial PBM has been studied for its potential therapeutic applications, including in the treatment of Alzheimer’s dementia, Parkinson’s disease, brain stroke, mood disorders, and cognitive enhancement. Transcranial PBM also results in activation of signaling pathways and transcription factors resulting in increased expression of genes related to protein synthesis, cell migration and proliferation, anti-inflammatory signaling, anti-apoptotic protein and antioxidant enzymes.